posted on 2022-11-03, 19:45authored byA. S. Tunis, Ralph E. Baddour, G. J. Czarnota, A. Giles, A. E. Worthington, Michael D. Sherar, Michael KoliosMichael Kolios
It has previously been demonstrated in tissue-mimicking phantoms and in tissue that envelope statistics of US
backscatter are affected by changes in the scatterer properties
[1–4, 32, 37]. At higher frequencies the
wavelength of the US begins to approach the size of cells and cellular
components and at this scale the envelope statistics of HFUS
backscatter become more sensitive to structural changes within
cells. To investigate the relation between the envelope statistics and cell
structure, experiments were performed in vitro. The physical meaning of the fit parameters
was evaluated by investigating HFUS backscatter from suspensions
of various concentrations of two different cell lines
of different sizes.