Design and testing of light stimulation for air travel jet lag alleviation

<p>Circadian dysrhythmia, commonly known as jet lag, is a prevalent condition affecting travelers who cross multiple time zones, which leads to significant physiological and cognitive disruptions. This thesis explores the design and optimization of light exposure schedules as a non-invasive intervention to mitigate jet lag symptoms by inducing controlled shifts in the human circadian rhythm. Using established mathematical models—specifically the Forger99 and Jewett99 models—this research quantifies circadian phase shifts in response to variations in light intensity and exposure duration over a 24-hour cycle. Through computational simulations and comparative analysis with empirical data from clinical trials, the study evaluates the effectiveness of different light exposure parameters. Key findings reveal that while both light intensity and duration significantly influence circadian phase shifts, duration has a unique effect on altering the phase</p> <p>response curve’s structure. The results inform the development of optimal periods to stimulate measured changes to circadian phase, and reveal the limitations of current mathematical circadian models. This research will contribute to the optimization of light therapy as a method of combatting jet lag, aiding in the development of effective in-flight interventions for circadian realignment.</p>