Correlation of Steady State and Transient Temperature Profiles in Perfused Fixed Kidneys: Implications for Thermal Models

Thermal models are used in hyperthermia to predict temperature distributions for treatment and applicator optimization. It is known that blood flow can significantly influence temperature profiles but an accurate description of this effect is unknown. Two models that have been used to model microvascular effects are the Pennes Bioheat Transfer Equation (BHTE) and the Effective Thermal Conductivity Equation (ETCE) [1], while an advection term is used in combination with the above to model large vessel effects [2]. The purpose of this work is to compare model predictions in an experimental system and to critically examine the effects of thermally significant vessels.