Toronto Metropolitan University
Browse
srep12141.pdf (8.98 MB)

Engineering functionalized multiphased silicon/silicon oxide nanobiomaterials to passivate the aggressive proliferation of cancer

Download (8.98 MB)
journal contribution
posted on 2022-12-17, 02:23 authored by Bo TanBo Tan, P. Premnath, Krishnan Venkatakrishnan

Currently, the use of nano silicon in cancer therapy is limited as drug delivery vehicles and markers in imaging, not as manipulative/controlling agents. This is due to limited properties that native states of nano silicon and silicon oxides offers. We introduce nano-functionalized multi-phased silicon/ silicon oxide biomaterials synthesized via ultrashort pulsed laser synthesis, with tunable properties that possess inherent cancer controlling properties that can passivate the progression of cancer. This nanostructured biomaterial is composed of individual functionalized nanoparticles made of a homogenous hybrid of multiple phases of silicon and silicon oxide in increasing concentration outwards from the core. The chemical properties of the proposed nanostructure such as number of phases, composition of phases and crystal orientation of each functionalized nanoparticle in the three dimensional nanostructure is defined based on precisely tuned ultrashort pulsed laser-material interaction mechanisms. The amorphous rich phased biomaterial shows a 30 fold (95%) reduction in number of cancer cells compared to bulk silicon in 48hours. Further, the size of the cancer cells reduces by 76% from 24 to 48hours. This method exposes untapped properties of combination of multiple phases of silicon oxides and its applications in cancer therapy

History

Language

English

Usage metrics

    Biomedical Engineering

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC