Dynamic light scattering optical coherence tomography to probe motion of subcellular scatterers

Dynamic light scattering OCT was performed on intact, control MCF-7 breast cancer cells and cells either treated with pacli- taxel to induce apoptosis or deprived of nutrients to induce oncosis. Autocorrelations (ACs) of the temporal fluctuations of OCT intensity signals demonstrate a significant decrease in decorrelation time after 24 h in both the paclitaxel-treated and nutrient-deprived cell groups but no significant differences between the two groups. The acquired ACs were then used as input for the CONTIN deconvolution algorithm, and all produced CONTIN outputs with three distinct peaks for all experimental conditions.