Development of an Accelerator Based Determination of Aluminum Burden in Peripheral Bone by Neutron Activation Analysis

[para. 1]: "Aluminum toxicity has been of interest since 1976, when the metal was first associated with a neurological syndrome called dialysis encephalopathy (Alfred, 1984). Since then it has been shown that an increase of aluminum burden in persons with kidney failure is the cause of renal osteodystrophy and osteomalacia (Wills and Savory, 1983). Alzheimer's disease has also been associated with aluminum, due to both finding aluminum in the brain of patients and studies showing an increased risk of AD in regions with high concentrations of aluminum in drinking water (Martyn et al., 1989)."