Development of CT texture analysis in COPD and association with visual scoring and DLCO

Objectives:

• To determine if CT texture features, such as GLCM and FD, can differentiate patients with COPD from healthy volunteers, and are related to lung function
• To determine if CT texture features are association with qualitative visual scoring
• To determine if CT texture features are significantly associated with COPD outcomes, independent of qualitative scoring and standard quantitative CT emphysema measurements 

Hypothesis:

• CT texture features can be developed to objectively aid in quantifying the severity of emphysema, and may provide information complementary to qualitative visual assessment