Caseinophosphopeptides and calcium biovailability

Bioactive peptides derived from the tryptic digestion of casein, known as caseinophosphopeptides (CPP), possess physicochemical properties that enable the chelation of various bi- and trivalent minerals, thereby enhancing mineral solubility in the lower small intestine. The significance of the interaction between CPP and calcium ions, in particular, for enhancing calcium absorption is presently a controversial issue due to the variations in the methodologies used to assess calcium biovailability.